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retroperitoneal fibrosis

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Retroperitoneal Fibrosis

Retroperitoneal fibrosis (RPF) is characterized by the development of extensive fibrosis throughout the retroperitoneum, typically centered over the anterior surface of the fourth and fifth lumbar vertebrae. This fibrosis leads to entrapment and obstruction of retroperitoneal structures, notably the ureters. In most cases, the etiology is unknown. However, its occasional association with autoimmune diseases and its response to corticosteroids and immunosuppressive therapy suggest it is probably immunologically mediated (Katz, 1977; Carton, 1969). Approximately 8% of cases may be associated with metastatic malignancy (Lepor, 1979).
المصدر
http://www.emedicine.com/med/topic3664.htm